Synthesis of some new 1,2,3-triazoles derivatives of D-mannose via click chemistry and evaluation of their effect on urease enzyme

Authors

Zeyad Kadhem oleiwi, Ezzat Hussein Zimam

Abstract

In this research some new 1,2,3-triazole derivatives of mannose were synthesized by click chemistry .The synthesis was started by the reaction of protected mannofuranose with propargyl bromide to form propargylic derivative of that sugar. The second step of synthesis was performed by preparation of aryl azide derivatives from diazoniume salts by treating them with sodium azide . Finally reaction of propargylic ether of mannose with aryl azide derivatives in click condition was gave triazole derivatives containing carbohydrate moiety . The biological activity of synthesized compounds were tested against urease activity . Some of these compounds ( Tr2,Tr3) show high inhibition action on the enzyme activity , while (Tr1)do not show any effect on the activity .

Keywords

Triazoles , D-mannose ,click chemistry , urease

Synthesis of some new 1,2,3-triazoles derivatives of D-mannose via click chemistry and evaluation of their effect on urease enzyme. Zeyad Kadhem oleiwi, Ezzat Hussein Zimam. 2015. IJIRCT, Volume 1, Issue 1. Pages 82-87. https://www.ijirct.org/viewPaper.php?paperId=IJIRCT1201021