Role and Evolution of Scaffold in Periodontal Regeneration- A Narrative Review
Author(s): Bhavna K. Pendam, Praneeta S. Kamble
Publication #: 2606018
Date of Publication: 13.09.2026
Country: India
Pages: 1-6
Published In: Volume 12 Issue 5 September-2026
Abstract
The goal of periodontal regeneration is to repair the periodontium along with its lost structural and functional integrity as a result of periodontal disorders. Scaffolds play an essential role in periodontal tissue engineering because they offer a three-dimensional framework for cell attachment, proliferation, differentiation, and extracellular matrix synthesis. The perfect scaffold should be mechanically stable, biocompatible, biodegradable, and capable of replicating the natural periodontal microenvironment while promoting the regeneration of intricate tissues, including cementum, periodontal ligament, and alveolar bone.
Collagen, chitosan, alginate, polylactic acid, and polycaprolactone are among the natural and synthetic biomaterials that have been investigated for scaffold production. Multiphasic and functionally graded scaffolds that more closely resemble the hierarchical architecture of periodontal tissues have been made possible by advancements in scaffold design, including electrospinning, 3D printing, and nanotechnology-based techniques. Additionally, incorporating stem cells, growth factors, and bioactive compounds into 3D-printed scaffolds has shown encouraging results in fostering tissue regeneration. More investigation will confirm its function and optimise its advantages in periodontal regeneration.
Keywords: Scaffold, Periodontal Regeneration, Tissue Engineering, 3D Printing, Scaffold biomaterials
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