Toxic and Carcinogenic Activity of Heavy metal Chromium in respect to Animals and Humans
Author(s): Asha Ram Meena
Publication #: 2512017
Date of Publication: 08.01.2025
Country: India
Pages: 1-4
Published In: Volume 11 Issue 1 January-2025
Abstract
Chromium is a common environmental pollutant because of its toxicity. Hexavalent chromium is a group 1 carcinogen that causes cancer through a variety of intricate processes. Chromosome breakage, increased oxidative stress, and DNA adduct production are a few of the main ways that Cr (VI) damages cells. The last century's industrial activities have significantly increased human exposure to heavy metals. Apoptosis, damage-repairing mechanisms, growth, proliferation, differentiation, and other cellular functions are all interfered with by heavy metals. When the methods of action of metals are compared, they are found to have comparable mechanisms of action, which include oxidative stress, ROS production, antioxidant defense weakness, and enzyme inactivation. This review will offer current research on both humans and animals to address the possible negative effects of exposure to Cr.
Keywords: Chromium, Carcinogen, Cellular damage, Heavy metal, Animal study
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