FORMULATION AND EVALUATION OF ONDANSETRON MOUTH DISSOLVING TABLETS FOR NAUSEA AND VOMITING
Author(s): H. Padmalatha
Publication #: 2511008
Date of Publication: 07.11.2025
Country: India
Pages: 1-11
Published In: Volume 11 Issue 6 November-2025
DOI: https://doi.org/10.62970/IJIRCT.v11.i6.2511008
Abstract
Ondansetron fast dissolving tablets were prepared by direct compression method using superdisintegrants is Pharmaburst ODT, in varying concentrations. Angle of repose: is 28° shows good flow. Bulk density and tapped density: is 0.410(g/ml) and 0.500 (g/ml), respectively. The values for compressibility index and Hausner ratio is 19.05 and 1.24, respectively. The results for pre-compressed parameters are shown in Table 15. Weight variation test is found 121.4 mg to 126.1 mg as per IP specification. Friability: Less than 0.31%, the results indicate that the percentage losses were not more than 1.0% (complies IP specifications). Thickness: Range from 2.90 mm to 2.99 mm; the results indicate that the tablets are suitable for packing. Content uniformity was found in between 98.62% and 100.3%. Hardness of the tablet was found to be between 4 to 4.6 kg/cm2. The results indicate that the tablets are mechanically strong and are in limit. Disintegration time which was in-between 0’11 sec to 0’16 sec, the results indicate that disintegration time of tablets is within 30 seconds. Dissolution study was carried out in 6.8 pH phosphate buffer for formulations FZ1, FZ2, FZ3, ZF4, FZ5, ZF6, FZ7, FZ8, and FZ9 from time 0 to 15 min And % assay for optimized batch was found to be 99.2 %. Comparative dissolution study was carried out in 6.8 pH phosphate buffer for formulations FZ9 and marketed product.
Keywords: Formulation, Evaluation, Ondansetron, Mouth Dissolving Tablets.
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