Anti-stress Activity Of Methanolic Extract Of Withania Coagulans Fruit On Chronic Unpredictable Stress Model In Mice
Author(s): Sakshi S. Alamwar, Dr. A. M. Wankhede, J.V. Vyas, Dr. V.V Paithankar
Publication #: 2405051
Date of Publication: 26.05.2024
Country: India
Pages: 1-8
Published In: Volume 10 Issue 3 May-2024
Abstract
Background: Chronic stress can have a wide range of health impacts, including an increased risk of neuropsychiatric diseases and immune response dysregulation. The chronic unpredictable stress (CUS) protocol is frequently used to research the impact of stress exposure in a variety of animal models and comprises of random, intermittent. CUS has regularly been proven to cause behavioural and immunological changes characteristic of the chronic stress response. The development of an alternate CUS procedure that allows mice to be used in chronic stress investigations is necessary. Here, we show that prolonging the CUS regimen to two weeks can elicit a chronic stress response in mice. We also saw stress-related behavioural changes, such as increased anxiety and depression, as well as decreased exploratory behaviour. Many anti-stress medications used today cause hazardous pharmacological responses.
Aim and objectives: To evaluate the effect of Anti-stress activity of withania coagulans fruit on chronic unpredictable stress model in mice.
Materials and methods: CUS paradigms are use to induce the stress and EPM and Marble burying test was used for check the behaviour response of mice where the EPM shows the positive effect and also marble burying shows the positive effect.
Result: There was statistically substantial (P<0.001) association observed between ethanolic extract of W. coagulans fruits with stress action in SAM by EPM and marble burying.
Conclusion: Recent psychiatry research has shown growing interest in herbal medication due to its improved compliance and fewer adverse effects. Flavonoids in herbal formulations have demonstrated promising effects on psychiatric illnesses, primarily through serotonergic and GABAergic activation. Further research is needed to fully understand the molecular mechanisms and neuropathological changes underlying their effectiveness in treating anti-stress conditions like Chronic Unpredictable Stress (CUS).
Keywords: CUS, neuroprotective, withania coagulans, anxiety, depressive-like behavior, compulsive or repetitive behaviors.
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