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Publication Number

2201002

 

Page Numbers

5-11

Paper Details

Aminofluorination: Transition-metal-free N–F Bond Insertion into Diazocarbonyl Compounds

Authors

Dr. Sudhir Kumar Mishra

Abstract

Gem-aminofluorination of diazocarbonyl compounds has been achieved for the first time. This reaction proceeds under mild conditions and does not require any transition-metal promoter or catalyst. Treatment of diazoesters with N-fluorobenzenesulfonimide (NFSI), which serves as both a fluorine and nitrogen source, results in the facile construction of C–N and C–F bonds, providing aminofluorination products in moderate to excellent yields. Kinetic studies and DFT calculations have provided valuable insight into the potential mechanism for this novel N–F bond insertion.

Keywords

Diazoacetate, Carbenoid Intermediates, Difunctionalization, Carbene, Aminofluorination, Bronsed Acids, Benzenesulfonimide

 

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Citation

Aminofluorination: Transition-metal-free N–F Bond Insertion into Diazocarbonyl Compounds. Dr. Sudhir Kumar Mishra. 2022. IJIRCT, Volume 8, Issue 1. Pages 5-11. https://www.ijirct.org/viewPaper.php?paperId=2201002

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