Synthesis of some new D-mannose glycosides based 1,2,3-triazoles as urease inhibitors
Author(s): Zeyad Kadhem oleiwi, Ezzat Hussein Zimam
Publication #: IJIRCT1201050
Date of Publication: 05.10.2015
Country: Iraq
Pages: 237-243
Published In: Volume 1 Issue 2 October-2015
Abstract
Williamson etherification of (1) with propargyl bromide afforded the 1-O-propargyl-2,3:5,6-Di-O-isopropyli-dene α-D-mannofuranoside (2) in a very good yield . 1,3-Dipolar cycloaddition of (2) with four different aryl azides derivatives using click conditions gave four novel 1,2,3-triazole derivatives containing sugar moiety . The biological activity of synthesized compounds were tested against urease activity by immobilize this enzyme on the synthesized compounds . All of these compounds show inhibition activity of enzyme. Some of these compounds (T1) show high inhibition action on the enzyme activity , while (T2,T3,T4) show moderate effect on the activity .
Keywords: D-mannose, glycoside , 1,2,3-triazole, urease, inhibitors.
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