editor@ijirct.org        

Published in:

Volume 1 Issue 2
October-2015
eISSN: 2454-5988

 

Unique Identifier

 

IJIRCT1201050


 

Page Number

 
237-243

 

 

Share This Article

 

 


Paper Details

Title

Synthesis of some new D-mannose glycosides based 1,2,3-triazoles as urease inhibitors


Abstract

Williamson etherification of (1) with propargyl bromide afforded the 1-O-propargyl-2,3:5,6-Di-O-isopropyli-dene α-D-mannofuranoside (2) in a very good yield . 1,3-Dipolar cycloaddition of (2) with four different aryl azides derivatives using click conditions gave four novel 1,2,3-triazole derivatives containing sugar moiety . The biological activity of synthesized compounds were tested against urease activity by immobilize this enzyme on the synthesized compounds . All of these compounds show inhibition activity of enzyme. Some of these compounds (T1) show high inhibition action on the enzyme activity , while (T2,T3,T4) show moderate effect on the activity .


Key Words

D-mannose, glycoside , 1,2,3-triazole, urease, inhibitors.

 

Click here for Article Preview

It appears you don't have Adobe Reader or PDF support in this web browser. Click here for view PDF

Download Paper

 

Print This Page

 

Download Citations

 

Download Counter

0018